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茶硷是哮喘儿童的常用药物,个体间茶硷清除率差异很大,可达7倍之多,但对每一个体来说,通过血清浓度的测定来确定适当剂量后,在长期服药过程中血清浓度即可稳定在治疗范围之内而很少变化。本文报道了1979年12月至1980年3月,在西雅图地区B型流感香港株和新加坡株引起的流感暴发中,作者观察到收入儿童矫形医院和医学中心(COHMC)的11例哮喘儿童,在患流感后茶硷清除率降低,出现茶硷中毒症状。11例患儿年龄自3岁至11.5岁,均有流感症状,在进行B型流感病毒抗体测定的10例中,有6例抗体效价在1:4以上。病例选择标准:
Theophylline is a commonly used drug for children with asthma. The clearance rate of theophylline among individuals varies greatly, up to 7 times, but for each individual, the appropriate dose is determined by the determination of serum concentration. After long-term medication Serum concentration can be stabilized within the treatment with little change. This paper reports 11 out of 11 children with asthma who were admitted to Children Orthopedic Hospital and Medical Center (COHMC) from December 1979 to March 1980 in an influenza outbreak in the Seattle area of Hong Kong strain B and Singapore. After suffering from influenza, the rate of theophylline clearance decreased, the symptoms of theophylline poisoning. Eleven of the children, aged from 3 to 11.5 years old, had influenza symptoms. Of the 10 patients who underwent influenza B virus antibody assay, 6 showed antibody titer of 1: 4 or higher. Case selection criteria: