SMZ合剂是甲氧苄胺嘧啶(TMP)和磺胺甲基异恶唑(SMZ)的合剂,近8～9年我国广泛用于临床。目前儿科已普遍用于治疗泌尿道,呼吸道及消化道感染。今复习文献,综述如下。一、SMZ合剂的作用方式 SMZ的化学结构和对氨苯甲酸类似,它能抑制二氢叶酸的合成。TMP抑制细菌二氢叶酸还原酶,阻止二氢叶酸还原为四氢叶酸。由于TMP和SMZ对细菌叶酸合成的序贯干扰,或谓细菌由于胸腺嘧啶核苷的合成受到抑制而致死亡。二、SMZ合剂的抗微生物范围 SMZ合剂对许多革兰氏阳性、阴性菌,以及某些非细菌性生物体都有作用。肠杆菌科特别敏感。一般敏感的有大肠杆菌,奇异变形杆菌,流感嗜血杆菌,肺炎双球菌,脑膜炎双球菌,志贺氏菌,伤寒杆菌,霍乱 SMZ mixture is trimethoprim (TMP) and sulfamethoxazole (SMZ) mixture, nearly 8 to 9 years in China widely used in clinical. Currently pediatric has been widely used to treat urinary tract, respiratory and gastrointestinal infections. This review of literature, summarized as follows. First, the mode of action SMZ mixture SMZ chemical structure and similar to ammonia, it can inhibit the synthesis of dihydrofolic acid. TMP inhibits bacterial dihydrofolate reductase and prevents dihydrofolate from reducing to tetrahydrofolate. Due to the sequential interference of TMP and SMZ on bacterial folic acid synthesis, or the death of bacteria due to the inhibition of thymidine synthesis. Second, the SMZ mixture antimicrobial range SMZ mixture on many Gram-positive, negative bacteria, as well as certain non-bacterial organisms have a role. Enterobacteriaceae are particularly sensitive. General susceptible Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Streptococcus pneumoniae, meningococcus, Shigella, Salmonella typhi, cholera