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目的:评价国产注射用奥沙利铂单药及与5-氟尿嘧啶(5-Fu)-四氢叶酸(CF)联合用于治疗大肠癌的疗效及毒副反应。方法:收治带瘤大肠癌患者49例,按随机方法,分别入单药组11例(单用奥沙利铂),联合组20例(奥沙利铂+5—Fu+CF),和对照组18例(5—Fu+CF)。结果:单药组有效率27.3％,联合组30.0％,对照组5.6％,单药组和联合组疗效高于对照组,且奥沙利铂对大肠癌常见转移部位如肝脏、腹腔淋巴结、盆腔及肺脏均可见临床疗效,毒副反应主要为神经感觉异常,其中重度异常单药组为9％,联合组为10％。结论:国产注射用奥沙利铂单用或联合5—Fu、CF治疗大肠癌疗效肯定,耐受性良好,值得临床进一步研究和扩大应用。
OBJECTIVE: To evaluate the efficacy and toxicity of homemade oxaliplatin injection and 5-fluorouracil (5-Fu)-tetrahydrofolate (CF) in the treatment of colorectal cancer. Methods: Forty-nine patients with tumor-bearing colorectal cancer were randomized and randomized to 11 patients in the monotherapy group (Oxaliplatin alone), and 20 patients in the combination group (Oxaliplatin+5-Fu+CF). Group 18 patients (5-Fu+CF). Results: The effective rate was 27.3% in the monotherapy group, 30.0% in the combined group and 5.6% in the control group. The curative effect of the monotherapy group and the combination group was higher than that of the control group, and the common metastatic sites of oxaliplatin on colorectal cancer were liver, abdominal lymph nodes, and pelvic cavity. The clinical efficacy was seen in both lungs and lungs, and the toxic and side effects were mainly neurosensory abnormalities, with severe abnormalities in the single drug group being 9% and in the combined group being 10%. Conclusion: The domestic injection of oxaliplatin alone or combined with 5-Fu, CF for the treatment of colorectal cancer is effective, well tolerated, and worthy of further clinical research and application.