论文部分内容阅读
目的研究葡激酶突变体(SakM)对高脂喂养大鼠血液常规的影响。方法选取60只Wistar大鼠,随机分为高脂药物组、高脂生理盐水组、正常药物对照组、正常生理盐水对照组,静脉注射SakM到大鼠体内,剂量按照0.5 mg/kg体重,2 d注射一次,连续15次,观察SakM对血液常规的影响。结果SakM对正常动物血液常规指标没有影响,但是能够改善高脂喂养动物的血液常规指标结论SakM长期使用不会影响正常动物血液常规指标,具有使用安全性,同时还能用来调节高脂喂养动物的血液常规指标。
Objective To study the effect of staphylokinase mutant (SakM) on the blood routine in high fat diet rats. Methods Sixty Wistar rats were randomly divided into high fat group, high fat group, normal saline group and normal saline control group. SakM was injected intravenously into rats. The dose was 0.5 mg / kg body weight, 2 d injection once a day for 15 times to observe the effect of SakM on blood routine. Results SakM had no effect on the blood routine indexes of normal animals, but could improve the blood routine indexes of high-fat-fed animals. Conclusion The long-term use of SakM does not affect the routine blood parameters of normal animals, has the safety of use, and can also be used to regulate the high fat-fed animals The blood routine.