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目的:探讨血清孕酮(P)和妊娠相关蛋白-A(PAPP-A)在早期诊断异位妊娠(EP)和稽留流产中的价值。方法:选择确诊的宫内早孕、异位妊娠患者各40例及稽留流产患者20例,用酶联免疫吸附法检测血清P、PAPP-A水平。结果:与宫内早孕组比较,异位妊娠和稽留流产组血清P和PAPP-A水平低于宫内早孕组,差异有统计学意义(P<0.05),异位妊娠组和稽留流产组之间比较,差异无统计学意义(P>0.05);同一孕周时,正常宫内早孕者血清PAPP-A的含量高于EP患者,且差异有统计学意义(P<0.05)。结论:血清孕酮、妊娠相关血浆蛋白A检测有助于异位妊娠和稽留流产的早期诊断。
Objective: To investigate the value of serum progesterone (P) and pregnancy-associated protein-A (PAPP-A) in the early diagnosis of ectopic pregnancy (EP) and missed abortion. Methods: Forty cases of early pregnancy and ectopic pregnancy diagnosed by intrauterine pregnancy and 20 cases of missed abortion were selected. Serum levels of P and PAPP-A were detected by enzyme-linked immunosorbent assay. Results: The levels of serum P and PAPP-A in ectopic pregnancy and missed abortion group were lower than those in intrauterine contraception group (P <0.05), while those in ectopic pregnancy group and missed abortion group There was no significant difference between the two groups (P> 0.05). In the same gestational week, the content of PAPP-A in normal intrauterine pregnancy was significantly higher than that in EP (P <0.05). Conclusion: Serum progesterone and pregnancy-related plasma protein A are helpful for the early diagnosis of ectopic pregnancy and missed abortion.