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目的:通过检测尿α1微球蛋白(α1-MG)的含量,说明其对于新生儿缺氧缺血性脑病(HIE)患儿肾损伤的早期诊断具有重要的临床意义。方法:收集我院30例HIE重度窒息患儿入院时第1、3、7天尿液,用放射免疫测定法(RIA)和酶联免疫吸附法(ELISA)两种方法联合测定尿α1-MG的含量,并与10例正常新生儿尿液指标进行对比来评价尿RBP在肾功能损伤中的作用。结果:通过两种方法检测的尿α1-MG在HIE组的不同天数数值均高于正常对照组(P<0.01),且随缺氧时间延长而逐渐升高。结论:两种方法联合检测结果证明尿α1-MG是评价HIE肾功能损害早期有价值的指标之一。
OBJECTIVE: To detect the content of urinary α1 microglobulin (α1-MG), which has important clinical significance for the early diagnosis of renal injury in neonates with hypoxic-ischemic encephalopathy (HIE). Methods: Urine was collected on the 1st, 3rd, 7th day after admission in 30 HIE children with severe asphyxia. Radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) were used to determine urinary α1-MG , And compared with 10 normal newborn urine indicators to evaluate the role of urinary RBP in renal injury. Results: The urinary α1-MG urinary α1-MG levels in the HIE group were higher than those in the normal control group (P <0.01), and gradually increased with the prolongation of hypoxia. Conclusion: The combined test results of two methods prove that urinary α1-MG is one of the valuable indicators to evaluate the early stage of renal dysfunction in HIE.