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作者分析日本骨髓移植中移植物抗宿主反应(GVHD)特点为:(1)154例同种骨髓移植中直接死亡原因为间质性肺炎者占34%,白血病复发占21%。感染占14%,GVHD居第4位占8%;(2)急性GVHD在1975—1985年内的同种骨髓移植中发病率为51—60%,慢性GVHD约为30%;(3)急性GVHD的发生与性别、年龄,是否接受全身分次照射,是否缓解,有无感染等无关;(4)急性GVHD的分级越高,慢性GVHD的发生率也越高;(5)急性白血病进行同种骨髓移植后发生急性GVHD者分级为0度、Ⅰ度与Ⅱ—Ⅳ度者的白血病复发率分别为37%,18%与19%。急性与慢性GVHD患
The authors analyzed the characteristics of graft-versus-host disease (GVHD) in bone marrow transplantation in Japan as follows: (1) Among the 154 cases of allogeneic bone marrow transplantation, 34% were due to interstitial pneumonia and 21% were relapsed. Infection accounted for 14%, and GVHD accounted for 8% of the 4th; (2) The incidence of acute GVHD in the same bone marrow transplantation in 1975-1985 was 51-60%, chronic GVHD was about 30%; (3) acute GVHD The occurrence of the GVHD is not related to gender, age, whether to receive whole-body fractional irradiation, whether it is relieved, and whether there is infection; (4) The higher the grade of acute GVHD, the higher the incidence of chronic GVHD; (5) The same kind of acute leukemia The incidence of leukemia recurrence in acute GVHD patients with grade 0, I, and II-IV after bone marrow transplantation was 37%, 18%, and 19%, respectively. Acute and chronic GVHD suffers