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肿瘤转移过程极其复杂,研究发现血小板与肿瘤血行转移密切相关,血小板可释放生物活性因子协助肿瘤细胞逃脱免疫监视,促进肿瘤细胞的上皮-间质转化(epithelial-mesenchymal transition,EMT)、增殖和侵袭能力,以加快肿瘤血行转移。近年来研究发现,血小板表面的C型凝集素样受体2(C-type lectin-like receptor-2,CLEC-2)与其配体平足蛋白(podoplanin,PDPN)结合后可激活血小板参与肿瘤的生长、迁徙和转移。应用抗CLEC-2抗体或阻断CLEC-2与PDPN的结合可能是抗肿瘤转移的一个新的研究方向,本文就CLEC-2在肿瘤血行转移中的作用及其临床应用前景进行综述。
The process of tumor metastasis is extremely complicated. The study found that platelets are closely related to the hematogenous metastasis of the tumor. The platelets can release bioactive factors to help tumor cells escape immune surveillance and promote the epithelial-mesenchymal transition (EMT), proliferation and invasion of tumor cells Ability to speed tumor metastasis. In recent years, it has been found that platelet surface C-type lectin-like receptor-2 (CLEC-2) binds to its ligand podoplanin (PDPN) Growth, migration and transfer. The application of anti-CLEC-2 antibody or blocking the binding of CLEC-2 to PDPN may be a new research direction of anti-tumor metastasis. This article reviews the role of CLEC-2 in tumor hematogenous metastasis and its clinical application prospects.