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目的:探索长链非编码RNA(lncRNA)AL049452在结直肠癌组织中的表达及临床意义。方法:收集84例手术切除的结直肠癌及相应的癌旁正常组织,q RT-PCR检测lncRNA-AL049452的表达水平,用Mann-Whitney U检验分析lncRNA-AL049452表达水平和结直肠癌患者临床病理特征的关系,同时分析其对结直肠癌患者的总生存时间及无病生存时间的影响。绘制ROC曲线评价lncRNA-AL049452诊断结直肠癌的效能。结果:结直肠癌患者肿瘤组织lncRNA-AL049452的表达水平明显高于癌旁正常组织(P=0.0035),肿瘤更大的结直肠癌患者其lncRNA-AL049452的表达量更高(P=0.024)。生存曲线分析显示,高表达lncRNA-AL049452的结直肠癌患者的无病生存时间较低表达组更短(log-rank=4.208,P=0.034)。ROC曲线分析显示,lncRNA-AL049452诊断结直肠癌的曲线下面积为0.723(95%CI=0.613~0.832,P<0.001),敏感性和特异性分别为86.0%和51.2%。结论:肿瘤组织中高表达的lncRNA-AL049452可能参与了结直肠癌发生发展进程,是结直肠癌诊断和预后判断的新生物标记物。
Objective: To explore the expression of long-chain non-coding RNA (lncRNA) AL049452 in colorectal cancer and its clinical significance. Methods: 84 cases of colorectal cancer and corresponding normal tissues were collected. The expression of lncRNA-AL049452 was detected by q RT-PCR. The expression of lncRNA-AL049452 and clinicopathological features of colorectal cancer were analyzed by Mann-Whitney U test Characteristics of the relationship, at the same time analysis of its colorectal cancer patients with total survival time and disease-free survival time. ROC curve was drawn to evaluate the efficacy of lncRNA-AL049452 in the diagnosis of colorectal cancer. Results: The expression of lncRNA-AL049452 in colorectal cancer was significantly higher than that in adjacent normal tissues (P = 0.0035). The expression of lncRNA-AL049452 was higher in patients with colorectal cancer (P = 0.024). Survival curve analysis showed that patients with colorectal cancer with high expression of lncRNA-AL049452 had shorter disease-free survival time (log-rank = 4.208, P = 0.034). ROC curve analysis showed that the area under the curve of lncRNA-AL049452 in diagnosing colorectal cancer was 0.723 (95% CI = 0.613-0.832, P <0.001), with a sensitivity and specificity of 86.0% and 51.2%, respectively. Conclusion: The high expression of lncRNA-AL049452 in tumor tissue may be involved in the development of colorectal cancer and is a new biomarker for the diagnosis and prognosis of colorectal cancer.