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目的:观察缺血性脑血管病患者应用阿司匹林后能否降低血浆溶血磷脂酸(LPA)含量。方法:1400例患者纳入本研究,其中803例诊为可能的缺血性脑血管病,343例为缺血性脑血管病。36名健康志愿者为对照组。LPA含量采用层析技术结合改良无机磷定量方法测定。结果:缺血性脑血管病组血浆LPA含量(3.11±1.55μmol/L)显著高于对照组(1.77±1.04μmol/L,P<0.001)。服用阿司匹林(80mg,1次/d)1个月可显著降低血浆中LPA含量。停服阿司匹林后1个月LPA含量再次升高(3.90±1.09μmol/L),明显高于服用阿司匹林时(1.93±0.85μmol/L,P<0.001)。结论:血浆LPA含量升高与血小板活化密切相关,口服阿司匹林可降低血浆LPA含量,这可能是阿司匹林预防缺血性卒中的机制之一。
Objective: To observe whether aspirin can reduce plasma lysophosphatidic acid (LPA) content in patients with ischemic cerebrovascular disease. METHODS: One hundred and forty-four patients were enrolled in this study, of whom 803 were diagnosed as probable ischemic cerebrovascular disease and 343 as ischemic cerebrovascular disease. 36 healthy volunteers as control group. LPA content was determined by chromatographic techniques combined with modified inorganic phosphorus quantification. Results: Plasma LPA level in ischemic cerebrovascular disease group (3.11 ± 1.55μmol / L) was significantly higher than that in control group (1.77 ± 1.04μmol / L, P <0.001). Taking aspirin (80mg, 1 time / d) for 1 month can significantly reduce the plasma LPA levels. The level of LPA increased again (3.90 ± 1.09μmol / L) one month after taking aspirin, which was significantly higher than that of taking aspirin (1.93 ± 0.85μmol / L, P <0.001). CONCLUSION: Elevated plasma LPA is closely related to platelet activation. Oral aspirin may reduce plasma LPA levels, which may be one of the mechanisms of aspirin in preventing ischemic stroke.