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目的探讨慢性高血压孕妇妊娠中期发生子痫前期的危险因素。方法抽选70例于2012年1—12月期间住院的慢性高血压孕妇,根据是否发生子痫前期分组,发生子痫前期38例为观察组,其余为对照组。计量资料采用t检测,对危险因素采用Logistic回归分析,P<0.05为差异有统计学意义。结果早、中期,组间孕妇的平均动脉压和尿蛋白量变化不明显,组间差异不明显,(P>0.05);妊娠后期,观察组平均动脉压和尿蛋白量大幅度增加,分别为(137.8±4.7)mm Hg(1 mm Hg=0.133 kPa)、(2.14±0.05)g/24 h,明显高于对照组(95.5±4.7)mm Hg和(0.18±0.02)g/24 h(均P<0.05);并且妊娠后期观察组孕妇的血生化指标水平均较对照组提升,其中Plt变化不明显;使用Logistic回归分析,Hb(OR值为1.22)、UA(OR值为1.82)、FDP(OR值为2.22)与子痫前期的发生密切相关。结论 Hb、UA、FDP等含量高代表血液凝度较高,血液高凝状态是子痫前期发生的危险因素,因此应密切监测血生化指标变化,早期进行治疗,降低子痫前期发生的危险性。
Objective To explore the risk factors of preeclampsia in the second trimester of pregnancy in chronic hypertensive patients. Methods Seventy patients with chronic hypertension who were admitted to hospital from January to December in 2012 were enrolled. According to whether preeclampsia occurred or not, 38 cases of preeclampsia were observed and the others were control group. Measurement data using t test, the risk factors using Logistic regression analysis, P <0.05 for the difference was statistically significant. Results The mean arterial pressure and urinary protein in pregnant women were not significantly different between the two groups (P> 0.05). The mean arterial pressure and urinary protein in the observation group increased significantly in the second trimester of pregnancy (137.8 ± 4.7) mmHg and (2.14 ± 0.05) g / 24 h were significantly higher than those in the control group (95.5 ± 4.7 mm Hg and 0.18 ± 0.02 g / 24 h (OR = 1.22), UA (OR = 1.82), FDP (P <0.05), and the levels of blood biochemical markers in pregnant women in the observation group were significantly higher than those in the control group (OR = 2.22) was closely related to the occurrence of preeclampsia. Conclusion High levels of Hb, UA and FDP represent the high blood coagulation and the hypercoagulable state of blood, which are risk factors of preeclampsia. Therefore, the changes of blood biochemical indexes should be closely monitored and treated early to reduce the risk of preeclampsia .