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根据猝死者的动态心电图分析,恰在致命性心律失常出现之前有心肌缺血,由流动冠心监护单位抢救的急性心肌梗塞在发生心室颤动(VF)之前确有心率增快。由此可见,交感亢进和急性心肌缺血可引起 VF 反复发作。急性心肌缺血主要通过左侧交感神经传入纤维兴奋心脏交感神经反射,又反射性地抑制迷走神经传向心脏的冲动,这在暂时降低 VF 阈值和冠状动脉闭塞早期的室性心律失常发生率中起主要作用。本研究通过动物模型判断各种抗心律失常药物的预防效果。
According to the sudden electrocardiogram analysis of sudden death, myocardial infarction occurred just prior to the onset of fatal arrhythmia. Acute myocardial infarction rescued by mobile coronary care units did have an increased heart rate before VF occurred. Thus, sympathetic hyperthyroidism and acute myocardial ischemia can cause recurrent episodes of VF. Acute myocardial ischemia is mainly caused by sympathetic reflex activation of the afferent fibers of the left sympathetic afferent nerve and reflexive inhibition of vagal afferent impulses to the heart, which temporarily reduces the incidence of VF threshold and early ventricular arrhythmia in patients with coronary artery occlusion is a main factor. This study uses animal models to determine the prophylactic effects of various antiarrhythmic drugs.