Cu doped ZnO nanocrystalline powder(10 mol%) has been found to be an efficient catalyst for the one‐pot multi‐component synthesis of fully substituted new indeno[1,2‐b]pyridines through a com-bination of 1,3‐indandione, propiophenone or acetophenone derivatives, aromatic aldehydes, and ammonium acetate in ethanol/H2 O at room temperature. The methodology is mild, efficient and high to excellent yielding. Cu doped ZnO nanocrystalline powder (10 mol%) has been found to be an efficient catalyst for the one-pot multi-component synthesis of fully substituted new indeno [1,2-b] pyridines through a com- bination of 1,3- indandione, propiophenone or acetophenone derivatives, aromatic aldehydes, and ammonium acetate in ethanol / H2 O at room temperature. The methodology is mild, efficient and high to excellent yielding.