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目的比较利巴韦林注射液、热毒宁注射液及喜炎平注射液治疗手足口病的临床疗效。方法选取2013年1月—2016年1月邢台市人民医院收治的手足口病患儿150例,按照随机数字表法将患儿分为A组、B组、C组,每组50例。A组患儿给予利巴韦林注射液治疗,B组患儿给予热毒宁注射液治疗,C组患儿给予喜炎平注射液治疗,3组患儿均连续治疗5 d。比较3组患儿体征消退时间、住院时间及临床疗效,并观察治疗期间不良反应发生情况。结果 C组患儿退热时间、皮疹消退时间、口腔溃疡愈合时间及住院时间均短于A组、B组(P<0.05)。C组患儿总有效率高于A组、B组(P<0.05);3组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论喜炎平注射液治疗手足口病的临床疗效优于利巴韦林注射液、热毒宁注射液,其可更有效缓解患儿临床症状,且安全性较高。
Objective To compare the clinical effects of Ribavirin Injection, Renduining Injection and Xiyanping Injection in the treatment of hand, foot and mouth disease. Methods 150 cases of hand, foot and mouth disease in Xingtai People’s Hospital from January 2013 to January 2016 were selected and divided into A group, B group and C group according to random number table method, with 50 cases in each group. A group of children given ribavirin injection treatment, B group given heat poisoning injection treatment, C group given Xiyanping injection treatment, three groups of children were treated for 5 consecutive days. The signs of subsided time, hospital stay and clinical efficacy were compared between the three groups, and the occurrence of adverse reactions during the treatment were observed. Results The antipyretic time, rash subsidence time, oral ulcer healing time and hospital stay in group C were shorter than those in group A and group B (P <0.05). The total effective rate of children in group C was higher than that in group A and B (P <0.05). There was no significant difference in the incidence of adverse reactions between the three groups (P> 0.05). Conclusion Xiyanping injection in the treatment of hand, foot and mouth disease is superior to the clinical efficacy of ribavirin injection, heat poisoning injection, which can be more effective in relieving clinical symptoms in children with high safety.