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目的:探讨糖尿病对CKD患者血清RBP4水平的影响和临床意义。方法:选取212例CKD1～5期患者及健康体检者24例,采用ELISA方法检测血清RBP4及甲状腺转运蛋白(TTR)的水平。结果:糖尿病对CKD患者血清RBP4水平影响的研究结果显示:CKD合并糖尿病组以及CKD不伴糖尿病组间eGFR、RBP4、RBP4/TTR水平差异无统计学意义;根据eGFR对患者进行分层研究,发现各组内糖尿病组与非糖尿病组的RBP4水平差异无统计学意义(CKD1～4,P>0.05)。而随着eGFR的下降,无论在糖尿病或非糖尿病患者中RBP4水平均明显升高。结论:随着eGFR的下降血清RBP4逐步升高,而RBP4水平与糖尿病之间差异无统计学意义相关。
Objective: To investigate the effect of diabetes on serum RBP4 level and its clinical significance in patients with CKD. Methods: Totally 212 patients with CKD stage 1-5 and 24 healthy subjects were enrolled in this study. Serum RBP4 and thyroid transport protein (TTR) levels were measured by ELISA. Results: The results of the study on the effect of diabetes on serum RBP4 level in CKD patients showed no significant difference in the levels of eGFR, RBP4 and RBP4 / TTR between patients with CKD and CKD without diabetes; according to the eGFR, the patients were stratified and found that RBP4 levels in diabetic group and non-diabetic group were not significantly different (CKD1 ~ 4, P> 0.05). With the decline of eGFR, RBP4 levels in both diabetic and non-diabetic patients were significantly increased. Conclusions: With the decline of eGFR serum RBP4 gradually increased, while there was no significant difference between RBP4 levels and diabetes mellitus.