目的阐明2002年1月至2012年12月间上海市杨浦区户籍人群膀胱癌的发病率和死亡率。方法系统整理上海市肿瘤登记报告系统中的杨浦区户籍人群膀胱癌发病和死亡资料,应用年均变化百分比(APC)模型分析患者发病率和死亡率的时间变化趋势,应用Kaplan-Meier模型结合Log-rank检验进行生存分析。采用2000年全国人口普查的标准人口年龄构成进行标化。结果 2002-2012年间膀胱癌新发患者1 252例,占同期全区新发恶性肿瘤的2.69%。膀胱癌年均粗发病率为10.51/105,其中男性为15.59/105,显著高于女性(5.18/105,P<0.01);标化发病率为4.83/105,其中男性标化发病率为7.26/105,高于女性(2.32/105,P<0.01)。2002-2012年间膀胱癌粗发病率明显上升(APC=4.14,P<0.01),但标化发病率无明显变化。50岁以后膀胱癌发病率迅速增加。因膀胱癌死亡690例。年均粗死亡率男性为8.61/105,女性为2.84/105(P<0.01);标化死亡率男性为3.64/105,女性为1.15/105(P<0.01)。2002-2012年间膀胱癌粗死亡率明显上升,标化死亡率未见明显改变。新发膀胱癌患者的5年生存率为63.15%,其中手术治疗组5年生存率为74.31%,高于非手术组(51.80%,P<0.01)。结论 2002-2012年间杨浦区户籍人群膀胱癌粗发病率和死亡率有明显的上升。手术治疗能显著提高患者生存期,提高膀胱癌早期诊断率和及时手术切除率有望提高患者整体生存。 Objective To clarify the incidence and mortality of bladder cancer in hukou households in Yangpu District of Shanghai from January 2002 to December 2012. Methods The incidence and mortality of bladder cancer in the household registration population in Yangpu district of Shanghai were systematically analyzed. The time-varying trend of morbidity and mortality was analyzed by using the average annual percentage change (APC) model. Kaplan-Meier model was used in combination with Log -rank test for survival analysis. The standard population age composition of the 2000 national census is used for standardization. Results A total of 1 252 cases of newly diagnosed bladder cancer between 2002 and 2012 accounted for 2.69% of newly diagnosed malignant tumors in the same period. The average annual incidence of bladder cancer was 10.51 / 105, of which 15.59 / 105 for men, which was significantly higher than that for women (5.18 / 105, P <0.01). The standardized incidence was 4.83 / 105, / 105, higher than female (2.32 / 105, P <0.01). The crude incidence of bladder cancer increased significantly from 2002 to 2012 (APC = 4.14, P <0.01), but there was no significant change in the incidence of bladder cancer. After the age of 50, the incidence of bladder cancer is rapidly increasing. 690 cases of bladder cancer death. The annual average crude death rate was 8.61 / 105 for males and 2.84 / 105 for females (P <0.01). The standardized mortality rate was 3.64 / 105 for males and 1.15 / 105 for females (P <0.01). The crude death rate of bladder cancer increased significantly from 2002 to 2012, with no significant change of standardized mortality. The 5-year survival rate of patients with new-onset bladder cancer was 63.15%. The 5-year survival rate was 74.31% in surgical treatment group, which was higher than that in non-operation group (51.80%, P <0.01). Conclusion The crude incidence rate and mortality rate of bladder cancer in registered permanent residents in Yangpu District increased significantly from 2002 to 2012. Surgical treatment can significantly improve the survival of patients, improve the early diagnosis of bladder cancer and timely surgical resection rate is expected to improve the overall survival of patients.