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目的初步探讨新生儿肺炎患儿检测痰液中降钙素原的临床意义。方法入选36例新生儿肺炎患儿,临床判断分为细菌感染组(21例)及非细菌感染组(15例),检测其痰液中降钙素原(PCT)和血清中PCT、血白细胞计数(WBC)、C-反应蛋白(CRP),做统计学处理。结果两组患儿痰液PCT、血清PCT比较差异有统计学意义(P<0.05),但血清CRP、WBC计数比较差异无统计学意义(P>0.05);痰液中PCT与血清PCT相关性较强(γs=0.712);肺炎细菌感染组痰液PCT、血清PCT阳性率均较血清CRP、血WBC计数高(P均<0.05),前两者比较差异无统计学意义(P>0.05);但痰液PCT浓度较血清PCT高。结论新生儿肺炎患儿痰液PCT和血清PCT均能很好提示肺部细菌感染,痰液PCT可能比血清PCT更早反映病情,因痰液取材简单且创伤少,对指导用药,减少抗生素滥用有较大意义。
Objective To investigate the clinical significance of procalcitonin in sputum in children with neonatal pneumonia. Methods Thirty-six neonates with pneumonia were enrolled in this study. The clinical diagnosis was divided into bacterial infection group (21 cases) and non-bacterial infection group (15 cases). The levels of PCT, serum PCT, Count (WBC), C-reactive protein (CRP), do statistical analysis. Results There were significant differences in sputum PCT and serum PCT between the two groups (P <0.05), but there was no significant difference in serum CRP and WBC count (P> 0.05). The correlation between PCT and serum PCT in sputum (P <0.05). There was no significant difference between the former two groups (P> 0.05). The sputum PCT and serum PCT positive rate of pneumonia bacterial infection group were higher than that of serum CRP and WBC count (P <0.05) ; However, sputum PCT concentration higher than serum PCT. Conclusions The sputum PCT and serum PCT in children with neonatal pneumonia can be a good indicator of bacterial infection in the lungs. The PCT of sputum may reflect the condition earlier than the serum PCT. Because sputum is simple and less invasive, it can guide the medication and reduce the abuse of antibiotics Have greater meaning.