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本文报道了照射前7—15min一次ip茵陈素40—60mg/kg,可提高~(60)Coγ线6—11Gy照射引起的造血型放射病大鼠30天的存活率为28.5％,其平均保护系数为1.940±0.8,对照射非亲系大鼠的剂量减低系数DRF值为1.149,且能提高照射鼠的体重变化百分率,增加照射大鼠的脾脏及胸腺重量;ip、po的给药时间分别以照前1/4、1h的抗放效果较好。ip 10—60mg/kg的范围内给药剂量对抗放效果影响不显著。本品对胃肠型急性放射病大鼠的预防效果欠佳。
This article reports that ip administration of 40- 60mg / kg of iphenracin 7-15min prior to irradiation can increase the 30-day survival rate of rats with hematopoietic radiation caused by irradiation of 6-11 Gy of ~ (60) Coγ line, and the average survival rate is 28.5% The coefficient was 1.940 ± 0.8, and the DRF value of irradiated non-relative rats was 1.149, which could increase the body weight percentage of irradiated mice and increase the weight of spleen and thymus in irradiated rats. The administration time of ip and po were In accordance with the previous 1/4, 1h anti-release effect is better. The dosage of ip 10-60mg / kg had no significant effect on the anti-release effect. The product of gastrointestinal acute radiation sickness in rats with poor prevention.