作者就氨苯砜(DDS)过敏反应问题复习了文献,并于1986年对应用 DDS 的一些中心作了信访调查。过去的文献中陆续报道了与 DDS 有关的许多不良反应,包括白细胞减少症、周围神经痛、中毒性表皮坏死松解症、低蛋白血症、光毒症、肾病综合征和溶血。还报道了使用大剂量 DDS 出现的毒性作用,包括肾损伤、溶血性黄疸、肝炎、高铁血红蛋白血症、精神病和视神经萎缩,不良反应 The author reviewed the literature on the allergic reaction to dapsone (DDS) and conducted a petition investigation of some of the centers using DDS in 1986. Many adverse reactions related to DDS have been reported in the past literature, including leucopenia, peripheral neuralgia, toxic epidermal necrolysis, hypoproteinemia, phototoxicosis, nephrotic syndrome and hemolysis. The toxic effects of high dose DDS were also reported, including kidney damage, hemolytic jaundice, hepatitis, methemoglobinemia, psychosis and optic atrophy, adverse reactions