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目的探讨缬沙坦对高血压患者左心室舒张功能的影响。方法采用自身对照开放试验方法,48例原发性高血压伴左心室舒张功能不全的患者口服缬沙坦80～160mg,1次/d,治疗8周。对治疗前后进行超声多普勒左心功能测量与对照分析。结果与治疗前相比,48例高血压患者治疗8周后,血压显著下降(P<0.01);超声多普勒对照检查显示,心肌重量指数(LVMI)、左心室后壁舒张末期厚度(LVPWT)、室间隔舒张末期厚度(IVST)以及峰值充盈速度A、峰值速度A/峰值速度E比值均明显下降(P<0.01)。结论缬沙坦在降压的同时,能逆转左心室肥厚,有效地改善左心室舒张功能。
Objective To investigate the effect of valsartan on left ventricular diastolic function in patients with essential hypertension. Methods A total of 48 patients with essential hypertension and left ventricular diastolic dysfunction were treated with valsartan 80 ~ 160 mg once daily for 8 weeks. Before and after treatment of ultrasound Doppler left ventricular function measurement and control analysis. Results Compared with those before treatment, blood pressure was significantly decreased in 48 hypertensive patients after 8 weeks of treatment (P <0.01). Contrast-enhanced ultrasound Doppler imaging showed that LVMI, LVPWT ), IVST, peak filling velocity A and peak velocity A / peak velocity E decreased significantly (P <0.01). Conclusion Valsartan can reverse left ventricular hypertrophy and relieve left ventricular diastolic function effectively.