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1 基本内容1.1 背景 本文讨论了炎性细胞粘附分子(CAMs)在缺血性卒中中的作用。血管内皮细胞和白细胞表达了几种炎性粘附分子受体,其中最重要的是选择素、免疫球蛋白基因超家族CAMs和β2整合素,它们介导白细胞通过血管内皮。1.2 综述概述 许多大脑中动脉阻塞的动物模型实验证明,CAMs的表达与脑梗塞灶大小有关。在基因敲除动物实验中,CAMs缺乏可使梗塞面积缩小。在实验性卒中中,大脑中动脉阻塞再灌注时,给予抗CAM
1 basics 1.1 Background This article discusses the role of inflammatory cell adhesion molecules (CAMs) in ischemic stroke. Vascular endothelial cells and leukocytes express several inflammatory adhesion molecule receptors, the most important of which are selectins, immunoglobulin gene superfamily CAMs and β2 integrins, which mediate the passage of leukocytes through the vascular endothelium. 1.2 Summary Overview Many animal model of middle cerebral artery occlusion experiments show that the expression of CAMs and cerebral infarction size. In knockout animal experiments, lack of CAMs can reduce infarct size. In experimental stroke, middle cerebral artery occlusion reperfusion, given anti-CAM