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目的探讨盐酸戊乙奎醚(商品名:长托宁)对急性有机磷农药中毒(AOPP)并发中间综合征(IMS)的治疗作用。方法 56例IMS患者随机分为治疗组和对照组,对照组常规使用阿托品、氯磷定和机械通气等治疗;治疗组用长托宁替代阿托品,其他治疗不变。比较2组机械通气所需的时间、住院天数和住院费用。结果治疗组和对照组的机械通气时间、住院天数、住院费用,分别为(3.36±1.56)d、(7.88±4.86)d、(9 398±3 969)元和(5.86±2.55)d、(11.36±6.38)d、(13 897±5 639)元,差异有统计学意义(P<0.05)。结论长托宁对IMS有确切的治疗作用,可缩短其疗程并减少患者住院费用。
Objective To investigate the therapeutic effect of penehyclidine hydrochloride (trade name: pendimethalin) on acute organophosphorus pesticide poisoning (AOPP) complicated with intermediate syndrome (IMS). Methods Fifty-six patients with IMS were randomly divided into treatment group and control group. The control group was treated with atropine, chlorophosphorus and mechanical ventilation. The treatment group was treated with atropine for a long period of time. Other treatments remained unchanged. The time required for mechanical ventilation, length of hospital stay and hospitalization were compared between the two groups. Results The duration of mechanical ventilation, length of hospital stay and hospitalization were (3.36 ± 1.56) d, (7.88 ± 4.86) d, (9 398 ± 3 969) and (5.86 ± 2.55) d respectively in the treatment group and the control group 11.36 ± 6.38) d, (13 897 ± 5 639) yuan, the difference was statistically significant (P <0.05). CONCLUSIONS: Therapeutic effect of penehyclidine on IMS has been shown to shorten its duration of treatment and reduce hospitalization costs.