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目的探讨不同剂量131Ⅰ对青壮年甲状腺功能亢进症近期疗效的影响。方法选择青壮年弥漫性甲状腺肿伴甲状腺功能亢进症患者200例,依据给药剂量分为小剂量组(n=110)和常规剂量组(n=90),比较两组131I治疗后的近期疗效。结果小剂量组和常规剂量组1年治愈率分别为81.82%(90/110)和86.67%(78/90),差异无统计学意义(P>0.05)。小剂量组早发甲状腺功能减低率为2.73%(3/110)明显低于常规剂量组的10%(9/90),差异有统计学意义(P<0.05)。两组治疗后甲状腺功能亢进症1年复发率分别为4.55%(5/110)和2.22%(2/90),差异无统计学意义(P>0.05)。结论小剂量131Ⅰ治疗青壮年甲状腺功能亢进症既可以达到明显的疗效,又可以降低早发性甲状腺功能低下的发生率。
Objective To investigate the effects of different doses of 131 Ⅰ on the recent efficacy of hyperthyroidism in young adults. Methods 200 young patients with diffuse goiter and hyperthyroidism were selected and divided into two groups according to the dosage: n = 110 and n = 90, and the short-term efficacy after 131I treatment was compared between the two groups . Results The 1-year cure rates of low dose group and conventional dose group were 81.82% (90/110) and 86.67% (78/90) respectively, with no significant difference (P> 0.05). The rate of early hypothyroidism was 2.73% (3/110) in the low dose group, which was significantly lower than that in the conventional dose group (9/90) (P <0.05). The one-year recurrence rates of hyperthyroidism after treatment were 4.55% (5/110) and 2.22% (2/90) respectively, with no significant difference (P> 0.05). Conclusion Small dose of 131 Ⅰ treatment of young and middle-aged hyperthyroidism can achieve obvious curative effect, but also can reduce the incidence of early hypothyroidism.