紫杉烷类(taxanes)是临床上常用的抗癌药,通过作用于β-微管蛋白阻滞细胞周期而诱导细胞凋亡。已知当干扰紫杉烷与微管结合的突变发生或多药转运蛋白P-糖蛋白表达上调时,将产生紫杉烷耐药。最近,Cohn等发现了紫杉醇耐药基因(Txr1),该基因下调凋亡诱导蛋白血小板反应蛋白(TSP1) Taxanes are clinically used anticancer drugs that induce apoptosis by acting on beta-tubulin to arrest the cell cycle. It is known that taxane resistance will result when mutations that interfere with the binding of taxanes to microtubules occur or the expression of the multidrug transporter P-glycoprotein is upregulated. Recently, Cohn et al. Discovered the taxol resistance gene (Txr1), which down-regulates apoptosis-inducing protein thrombospondin (TSP1)