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目的:观察支气管镜下对肺结核合并感染局部病灶灌注效果与安全性。方法:2013年2月-2014年1月住院患者37例,随机分灌注治疗组(21例)和对照组(16例),灌注治疗组,术中镜下灌注(异烟肼0.4mg+10ml生理盐水、阿米卡星0.4mg+5ml生理盐水。对照组,口服抗结核药+抗菌素,观察支气管镜下痰液颜色和痰量的改变、黏膜充血、水肿吸收程度,CT病灶缩小范围为判定标准,第一周俩次镜下灌注,后三周,每周一次,治疗4周时间为观察期。结果:治疗组镜下观察痰液明显减小,颜色由黄色转白,黏膜充血、水肿吸收,黏膜出现光滑、红润,CT片病灶缩小或吸收。结论:支气管镜下局部病灶灌注治疗结核合并感染,是临床一项有效辅助手段,且副作用少。
Objective: To observe the effect and safety of bronchoscopy on perfusion of local lesions in pulmonary tuberculosis complicated by infection. Methods: From February 2013 to January 2014, 37 hospitalized patients were randomly divided into two groups: perfusion treatment group (21 cases) and control group (16 cases). The patients in the perfusion group received intraoperative perfusion of isoniazid 0.4 mg + Saline, amikacin 0.4mg + 5ml saline. The control group, oral anti-tuberculosis drugs + antibiotics to observe changes in bronchoscopy sputum color and sputum volume, mucosal congestion, edema absorption, CT lesion narrowed to determine Standard, the first week of two times the second perfusion, after three weeks, once a week, the treatment of 4 weeks for the observation period.Results: The treatment group was significantly reduced sputum observed microscopy, the color from yellow to white, mucosal congestion, edema Absorption, mucosal smooth, ruddy, CT lesion shrink or absorption.Conclusion: Bronchoscopic local lesion perfusion treatment of tuberculosis infection, is an effective clinical adjuvant, with few side effects.