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新霉素最初是 Waksman 和 Lechevalier 于1949年由 Stretomyces frcdiae 3535和3554的发酵液中提取得到的。新霉素是一个碱性物质,具有强烈抑制格兰氏阳性、格兰氏阴性细菌及结核分枝杆菌的能力。试验观察中发觉新霉素有处理治疗对其他化学治疗剂有抵抗性细菌引起病例的可能性,不幸新霉素分子中不可分离的有毒性质限制了它在临床上的广泛应用。
Neomycin was originally obtained from the fermentation broth of Streptomyces frcdiae 3535 and 3554 by Waksman and Lechevalier in 1949. Neomycin is an alkaline substance with a strong ability to inhibit Gram-positive, Gram-negative bacteria and Mycobacterium tuberculosis. In the experimental observation, we found that neomycin has the possibility of treating the cases caused by bacteria resistant to other chemotherapeutic agents. Unfortunately, the inseparable toxic nature of neomycin molecules limits its wide application in clinic.