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目的分析戊酸雌二醇联合米索前列醇在绝经后取环中的作用。方法将60例绝经后要求取环的妇女随机分成观察组(30例)和对照组(30例)。观察组在取环术前1周每日口服戊酸雌二醇2mg,术前2h口服米索前列醇200μg,对照组不用任何药物。比较两组受术者在宫颈软化程度、疼痛及手术成功率等方面的差异。结果观察组30例(100%)取器成功,宫颈全部软化,4例(10.3%)需要扩宫,疼痛轻度22例(73.3%),中度8例(23.7%);对照组30例中5人(占16.7%)宫颈硬,宫口未开,取环失败,13人(占43.3%)宫口紧,经用宫颈扩张器后顺利取器,疼痛轻度3例(10%),中度13例(43.4%),重度14例(46.6%)。两组在宫颈软化程度、术中疼痛情况、手术成功率等方面差异均有统计学意义(P<0.01)。结论戊酸雌二醇联合米索前列醇用于绝经后取环能使宫颈软化,减轻受术者痛苦,提高手术成功率,值得临床应用。
Objective To analyze the role of estradiol valerate in combination with misoprostol in postmenopausal patients. Methods Sixty postmenopausal women were recruited into the observation group (30 cases) and the control group (30 cases). In the observation group, 2 mg estradiol valerate was orally administered daily for 1 week before taking cyclophosphamide, and 200 μg of misoprostol was administered 2 h before surgery. The control group received no medication. The differences between the two groups in the degree of cervical softening, pain and surgical success rate were compared. Results In the observation group, 30 cases (100%) were successful in taking the device and the cervix was all softened. Four patients (10.3%) needed to be dilated. The pain was mild in 22 cases (73.3%) and moderate in 8 cases (23.7% 5 (16.7%) had cervical stiffness, cervix was not open, failed to take the ring, and 13 (43.3%) had cervix tightness. , Moderate in 13 cases (43.4%) and severe in 14 cases (46.6%). There were significant differences between the two groups in the degree of cervical softening, intraoperative pain, the success rate of operation and so on (P <0.01). Conclusion The combination of estradiol valerate and misoprostol for postmenopausal cervical ring can soften the cervix, relieve the suffering of the surgeon and improve the success rate of operation, which is worthy of clinical application.