论文部分内容阅读
用过氧化物酶抗过氧化物酶(PAP)免疫组织化学法测定13例膀胱癌细胞雌激素受体(ER)。结果表示有8例(61%)ER(+)。而膀胱非癌组织 ER(-)。同时观察到膀胱癌细胞形态学相同,但 ER 的异质分布则可存在或缺如。临床分析提示,ER(-)者无痛性血尿病程长和肿瘤生长缓慢。ER(+)者无痛性血尿病程短,而且肿瘤生长迅速,广基和易浸润肌层并为多病灶性。膀胱癌细胞的 ER 可能是影响肿瘤生物行为的新标志物,亦可能提出新的治疗观点。
Thirteen bladder cancer cell estrogen receptors (ER) were measured by peroxidase anti-peroxidase (PAP) immunohistochemistry. The results showed 8 cases (61%) of ER(+). The bladder non-cancer tissue ER (-). At the same time, the morphology of bladder cancer cells was observed to be the same, but the heterogeneity of ER distribution may be present or absent. Clinical analysis suggested that the duration of painless hematuria in ER(-) patients and the tumor growth were slow. ER (+) painless hematuria has a short duration, and the tumor grows rapidly, broad-based and easily infiltrated muscular layers and multifocal. The ER of bladder cancer cells may be a new marker that influences the biological behavior of tumors, and it may also propose new treatment perspectives.