中药三类新药清肝胶囊由黄连、赤芍、青黛等六味中药组成 ,其中黄连为君药。据报道 ,黄连中所含的盐酸小檗碱占总生物碱的 55%～ 67% [1] ,盐酸小檗碱是黄连清热解毒作用的有效成分之一 [2 ]。本文以盐酸小檗碱为指标成分 ,对该药进行含量测定研究 ,并取得满意的结果。1　仪器 The three types of Chinese medicine Qinggan capsules consist of six Chinese herbal medicines, including Coptis, Radix paeoniae, and Cinnamomum, among which Coptis is the king drug. According to reports, berberine hydrochloride contained in Huanglian Zhong accounted for 55% to 67% of the total alkaloids [1], and berberine hydrochloride was one of the effective components of the detoxification effect of Huanglian Qingre [2]. In this article, berberine hydrochloride was used as the index component to determine the content of this drug, and satisfactory results were obtained. 1 Instrument