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晚期糖基化终产物受体是细胞表面分子中免疫球蛋白超家族的一个多配体成员,是一处具有多配全的跨膜信号转导受体。它与不同的配体结合后,在不同的生理病理过程中发挥不同的作用。其中与肿瘤密切相关的配体是神经轴突生长因子。在许多恶性肿瘤中两者均表达增高,并且与肿瘤细胞的增殖、运动、侵袭转移能力及肿瘤临床分期与预后等相关。对两者结构和功能以及相互作用的认识与研究,可能为肿瘤的治疗提供新的靶位区,因此具有非常重要的临床意义。
The receptor for advanced glycation end products is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules that is a multifunctional transmembrane signal transduction receptor. It binds to different ligands and plays different roles in different physiological and pathological processes. Among them, the ligand closely related to tumor is axon growth factor. Both are expressed in many malignant tumors, and are related to tumor cell proliferation, movement, invasion and metastasis, clinical stage and prognosis of tumors. Understanding and studying the structure and function of both and their interaction may provide a new target region for the treatment of tumors, and therefore have very important clinical significance.