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为观察三苯双脒对两种钩虫感染的治疗效果及副反应。用三苯双脒 2 0 0 m g、30 0 mg和 40 0 mg顿服治疗成人钩虫感染者 ,并与阿苯达唑 40 0 m g顿服进行比较。结果三苯双脒 2 0 0 mg、30 0 m g和 40 0 m g的虫卵阴转率分别为 5 2 .78%、77.78%和 86 .17% ,阿苯达唑 40 0 mg的虫卵阴转率为 6 6 .2 9%。服三苯双脒在 12 h后开始排虫 ,36 h累积排虫达 95 %以上 ,第 3d基本排净。副作用轻微 ,对血象、肝、肾功能和心电图无明显影响。三苯双脒对美洲钩虫和十二指肠钩虫均有显著疗效。
To observe the efficacy of tribenzamidine on two hookworm infections and side effects. Adults with hookworm infection were treated with tribendimidine at 200 m g, 300 mg and 40 mg daily doses, and compared with albendazole at 40 m daily. Results The insecticidal rates of triphenylbutylamines at 2 0 0 mg, 30 0 mg and 40 0 mg were 52.78%, 77.78% and 86.17%, respectively, and albendazole 40 0 mg Turnover was 6 6 .29%. Tribendimidine service began to arrange worms 12 h later, and the accumulations of up to 95% were accumulated in 36 h. Minor side effects on the blood, liver, kidney function and ECG had no significant effect. Tribenzoamidine has obvious curative effect on American hookworm and duodenal hookworm.