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目的 :测定、比较经腹腔动脉和周围静脉注射 5 -氟尿嘧啶 (5 -Fu)后体循环周围静脉血及胰腺、肝脏组织内的药代动力学变化。方法 :家兔 2 0只 ,随机分为腹腔动脉给药组 (CA) (n =1 0 )和周围静脉给药组 (PV) (n =1 0 ) ,按 40mg/kg体重注入 5 -Fu。注药后定时取颈动脉血及胰腺和肝脏组织。高效液相色谱法 (HPLC)测定血及组织中的 5 -Fu浓度。结果 :CA组和PV组快速注射大剂量的 5 -Fu后 ,血中的药物浓度变化相似。CA给药能提高胰腺的药物浓度 ,在给药后 1 0、2 0、30分钟CA组是PV组的 57、2 9、6倍。 60分钟时两者相似。 60分钟后PV组又以较CA组为快的速度衰减。CA给药和PV给药肝脏的药物浓度变化和胰腺相似。结论 :CA给药可在 60分钟内提高胰腺、肝脏的药物浓度 ,从而提高胰腺癌化疗效果并预防肝转移的发生。
Objective : To determine and compare the pharmacokinetics of peripheral venous blood, pancreatic and hepatic tissue after 5-fluorouracil (5-Fu) injection into celiac artery and peripheral vein. METHODS: Twenty rabbits were randomly divided into celiac artery administration group (CA) (n = 10) and peripheral intravenous administration group (PV) (n = 10). 5 -Fu was injected at 40 mg/kg body weight. . Carotid blood and pancreas and liver tissue were taken periodically after injection. High-performance liquid chromatography (HPLC) was used to determine the concentration of 5-Fu in blood and tissues. RESULTS: After rapid injection of large doses of 5-Fu in CA and PV groups, the changes in blood drug concentrations were similar. CA administration increased the pancreatic drug concentration, and the CA group was 57, 29, and 6 times the PV group at 10, 20, and 30 minutes after administration. The two are similar at 60 minutes. After 60 minutes, the PV group attenuated faster than the CA group. Changes in drug concentration in the CA administration and PV administration to the liver were similar to those in the pancreas. Conclusion: CA administration can increase the concentration of drugs in the pancreas and liver in 60 minutes, thereby improving the chemotherapy effect of pancreatic cancer and preventing the occurrence of liver metastasis.