本文就整合素在中枢神经系统中的表达 ,特别是在脑胶质瘤中的表达及变化 ,着重阐述了整合素对胶质瘤生长尤其是在胶质瘤浸润中的关键作用 ,揭示某些整合素的低表达或丧失使得肿瘤细胞失去对来自细胞基质分化信号的反应 ,促进缺乏分化的肿瘤细胞形成。介导与ECM蛋白或其混合物反应的整合素低表达或者功能低调可能在肿瘤细胞脱离原发灶发生浸润或转移中起了重要作用。参与细胞迁移的整合素高表达可能促进浸润细胞穿过细胞间质 This article focuses on the expression of integrins in the central nervous system, especially in gliomas, and highlights the key role of integrins in glioma growth, especially glioma invasion, revealing some The low expression or loss of integrins causes tumor cells to lose their response to signals from the stromal differentiation of cells and promote the formation of tumor cells lacking differentiation. The mediation of low expression or low function of integrins that react with ECM proteins or their mixtures may play an important role in the invasion or metastasis of tumor cells from the primary tumor. The high expression of integrins involved in cell migration may promote the infiltration of infiltrating cells across the interstitium