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纤粘连蛋白是一种主要的细胞外基质,能够与整合素相互作用,介导胚泡的粘附和扩展.首次发现与纤粘连蛋白共同培养的小鼠胚泡产生基质金属蛋白酶-2和-9;若无纤粘连蛋白,小鼠胚泡不产生基质金属蛋白酶-2和-9;焦点粘着激酶是整合素信号转导通路中的关键信号分子,其反义寡聚脱氧核酸显著抑制纤粘连蛋白诱导的胚泡基质金属蛋白酶活性.结果表明,纤粘连蛋白可能通过其整合素受体的信号转导通路,启动小鼠胚泡基质金属蛋白酶-2和-9的表达,协调胚泡的侵入能力和子宫内膜的接受能力,从时间和空间上保证植入相关事件的准确性.
Fibronectin is a major extracellular matrix that interacts with integrins and mediates blastocyst adhesion and expansion. It was first found that mouse blastocysts co-cultured with fibronectin produce matrix metalloproteinase-2 and -9; in the absence of fibronectin, mouse blastocysts do not produce matrix metalloproteinase-2 and -9; focal adhesion kinase is an integrin Signal transduction pathway of the key signaling molecules, the antisense oligodeoxynucleotides significantly inhibited fibronectin-induced blastocyst matrix metalloproteinase activity. The results showed that fibronectin could initiate the expression of matrix metalloproteinase-2 and -9 in mouse blastocyst through the signal transduction pathway of its integrin receptor, and coordinate the blastocyst invasion ability and endometrial receptivity. From Time and space to ensure the accuracy of implant-related events.