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作者对5只2.5～4.5岁、体重为8～14kg的黑猩猩〔丙氨酸转氨酶(ALT)和肝组织学检查均正常〕静脉注射1ml含10~(3.5)黑猩猩感染剂量(CID_(50))的ayw亚型乙型肝炎病毒(HBV)。随后于第4、8、48和72小时分别在4只黑猩猩的大腿肌肉接种20μg血源性乙型肝炎疫苗,于接种第1针后的第2和第6周分别接种第2和第3针疫苗。1只黑猩猩不接种疫苗,作为HBV传染性对照。从接触HBV起,对5只黑猩猩每周采血检测ALT、HBsAg、抗-HBs和抗-HBc,每3周作1次肝组织活检,共观察1年。结果表明,接种第2针疫苗后1周,所
The authors injected intravenous injection of 1 ml (CID 50) of 10-3.5 chimpanzee into five chimpanzees 2.5 to 4.5 years old weighing 8 to 14 kg [ALT and liver histology were normal] Of ayw subtype hepatitis B virus (HBV). Subsequently, four chimpanzees’ thigh muscles were inoculated with 20 μg of blood-borne hepatitis B vaccine respectively at 4, 8, 48 and 72 hours, and the second and third needles were inoculated on the 2nd and the 6th week after inoculation of the 1st needle vaccine. One chimpanzee was unvaccinated as an infectious HBV control. From exposure to HBV, five chimpanzees were collected weekly for ALT, HBsAg, anti-HBs and anti-HBc, and liver biopsies were performed every 3 weeks for a total of 1 year. The results showed that vaccination with the first 2 weeks after the vaccine, the