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目的：阐明单纯放射治疗恶性肉芽肿的远期疗效及其和预后有关的某些因素。材料与方法：本文回顾性分析了北京医院放疗科目１９８０年１月至１９９１年６月共收治的病理诊断为恶性肉芽肿的患者３９例，中位年龄４０岁。原发病变累及早个解剖部位的占２３例（５９％），累及２个或２个以上解剖部位的１６例（４１％）：伴有发热症状者１４例（３６％）：分别于放疗始、放疗中、放疗终给予环已亚硝脲（ＣＣＮＵ）１００－１２０ｍｇ的患者８例（２０．５％）。全组均来用体外照射，８２％的患考肿瘤剂量ＤＴ为５０－６０Ｇｙ／５－６周。结果：全组３年，５年，１０年生存率分别为７４％，６３％及４５％。病变累及单个解剖部位的较累及２个或２个以上解部部位的３年，５年生存率高（Ｐ值均等于０．０３），但１０年生存率统计学无显著差别（Ｐ＝０．２０）。配合使用ＣＣＮＵ对疗效无影响。比较有无发热症状的３年，５年，１０年生存率无显著差异。１０年以上生存者远期放射反应轻微。结论：放射治疗恶性肉芽肿的远期效果良好，肿瘤吸收剂量以５０～６０Ｇｙ／５－６周为宜。
Objective: To clarify the long-term efficacy of simple radiotherapy for malignant granuloma and its prognosis-related factors. Materials and Methods: This paper retrospectively analyzed 39 cases of pathologically diagnosed malignant granuloma in Beijing Hospital from January 1980 to June 1991, with a median age of 40 years. Twenty-three patients (59%) had primary lesion involving early anatomic sites and 16 patients (41%) involving two or more anatomical sites: 14 patients (36%) with fever, at the beginning of radiotherapy In radiotherapy, 8 patients (20.5%) were treated with 100-120 mg of nitrosourea (CCNU). All groups were exposed to in vitro irradiation, 82% of the test tumor dose DT was 50-60Gy / 5-6 weeks. Results: The 3-year, 5-year and 10-year survival rates of the whole group were 74%, 63% and 45% respectively. The 3-year and 5-year survival rates were significantly higher in patients with lesions involving more than 2 or more solitary sites (P = 0.03), but there was no significant difference in 10-year survival rates (P = 0 .20). With the use of CCNU no effect on the efficacy. There was no significant difference in the 3-year, 5-year and 10-year survival rates comparing with or without fever symptoms. Long-term radioresistance of survivors over 10 years is minor. Conclusion: The long-term effect of radiotherapy for malignant granuloma is good, and the absorbed dose of tumor is 50-60 Gy / 5-6 weeks.