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目的经皮冠状动脉介入治疗(PCI)冠心病(CHD)患者外周血髓过氧化物酶(MPO)水平的影响。方法选取2013年12月至2015年1月驻马店市中心医院收治的89例CHD患者作为研究对象,采用随机数字表法将其分为试验组(46例)和对照组(43例)。对照组患者行冠状动脉造影术,试验组患者行经皮冠状动脉介入术,比较两组患者血清髓过氧化物酶(MPO)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平及中性粒细胞浓度。结果试验组患者血清MPO、IL-6水平均明显高于对照组,差异均有统计学意义(均P<0.05)。两组患者hs-CRP水平及中性粒细胞浓度差异均无统计学意义。结论 MPO水平可以评价CHD患者PCI后的危险性,有助于分级评价,提高临床预警水平,以便及时对患者进行术后危险事件的救治,提高预防效果,改善预后。
Objective To investigate the effect of MPO in peripheral blood of patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). Methods Eighty-nine CHD patients admitted from January 2013 to January 2015 in Zhumadian Central Hospital were enrolled in this study. They were divided into experimental group (46 cases) and control group (43 cases) by random number table. The patients in the control group underwent coronary angiography. The patients in the test group underwent percutaneous coronary intervention. The levels of serum MPO, hs-CRP, IL-6) levels and neutrophil concentration. Results The levels of serum MPO and IL-6 in the experimental group were significantly higher than those in the control group (all P <0.05). There was no significant difference in hs-CRP level and neutrophil concentration between the two groups. Conclusion The level of MPO can be used to evaluate the risk of PCI in patients with CHD, contribute to the classification evaluation and improve the level of clinical warning, so as to promptly treat the patients with postoperative risk events, improve the prevention effect and improve the prognosis.