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目的研究儿童肥胖发生过程中趋化因子、炎症因子和C-反应蛋白(CRP)的作用,探讨儿童肥胖与上述因子的关系。方法选择2014年1-12月该院83例单纯性肥胖患儿作为研究对象,同时选择83例健康儿童作为对照组,研究两组的一般指标、趋化因子、炎症因子、超敏C反应蛋白(hs-CRP)的水平。结果体质量、体质量指数、腰围、臀围、腰臀比、血糖、胰岛素、胰岛素抵抗指数(HOMA-IR)等项目研究组均高于对照组,且差异均有统计学意义(均P<0.05);肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、hs-CRP、单核细胞趋化蛋白-1(MCP-1)、巨噬细胞炎性蛋白-1α(MIP-1α)等平均值研究组均高于对照组,差异均有统计学意义(均P<0.05);TNF-α、IL-6、hs-CRP、MCP-1、MIP-1α与BMI、HOMA-IR等均呈正相关(P<0.05)。结论慢性炎症在肥胖的发生发展中发挥着重要作用,阐明慢性炎症的发生机制有助于改进治疗方式,增加治疗效果。
Objective To study the role of chemokines, inflammatory cytokines and C-reactive protein (CRP) in childhood obesity and to explore the relationship between childhood obesity and these factors. Methods Eighty-three simple obese children from January to December 2014 in our hospital were selected as research objects. Eighty-three healthy children were selected as control group. The general indexes, chemokines, inflammatory factors, high sensitivity C-reactive protein (hs-CRP) levels. Results The body mass, body mass index, waist circumference, hip circumference, waist-hip ratio, blood glucose, insulin and insulin resistance index (HOMA-IR) were significantly higher in the study group than in the control group (all P < 0.05). The levels of TNF-α, IL-6, hs-CRP, MCP-1 and macrophage inflammatory protein- The levels of TNF-α, IL-6, hs-CRP, MCP-1, MIP-1α in the study group were higher than those in the control group (all P <0.05) BMI, HOMA-IR, etc. (P <0.05). Conclusion Chronic inflammation plays an important role in the development of obesity. To clarify the mechanism of chronic inflammation helps to improve the treatment and increase the therapeutic effect.