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目的探讨贲门癌组织中黏蛋白-1(MUC-1)又称为多形上皮黏蛋白(PEM)与β-连环蛋白(β-Catenin)异常表达的意义,以及其与贲门癌临床分期、组织学类型、肿瘤发生部位、肿瘤大小等临床病理学关系。方法采用HE染色切片进行组织病理学分类,免疫组织化学法(SP)检测70例贲门癌组织、癌旁组织、远癌组织中的多形上皮黏蛋白(PEM)与β-连环蛋白(β-Catenin)的表达。结果①MUC-1、β-Catenin在远癌组织贲门黏膜上皮细胞中的阳性表达率分别为15.71%(11/70)、1.43%(1/70),在癌旁组织中的表达率为34.29%(24/70)、41.43%(29/70),而在贲门癌中的阳性表达率是54.29%(38/70)、58.57%(41/70)。②二者在有淋巴结组与无淋巴结转移组的表达不具有显著性差异(P>0.05)。③二者在不同临床分期、不同分化程度的蛋白表达不具有显著性差异(P>0.05)。④二者在肿瘤大小、不同年龄段、不同性别中蛋白表达均不具有显著性差异(P>0.05)。⑤MUC-1与β-Catenin在贲门癌表达中具有协同作用(相关系数为0.9072,P=0.0001<0.05)。
Objective To investigate the significance of mucin-1 (MUC-1), also known as polymorphonuclear ectopic mucosa (PEM) and beta-catenin in gastric cardia carcinoma, and its relationship with clinical stage, Type of study, location of tumor, tumor size and other clinicopathological relationships. Methods Histopathological sections were made by HE staining. Immunohistochemistry (SP) was used to detect the expression of polymorphonuclear mucin (PEM) and β-catenin (β-catenin) in 70 cases of gastric cardia cancer tissues, Catenin expression. Results ① The positive expression rates of MUC-1 and β-Catenin in far gastric cardia epithelial cells were 15.71% (11/70) and 1.43% (1/70), respectively. The positive rates of MUC-1 and β-Catenin were 34.29% (24/70) and 41.43% (29/70), respectively. The positive rates in cardia cancer were 54.29% (38/70) and 58.57% (41/70) respectively. ② There was no significant difference between the two groups in lymph node metastasis and non-lymph node metastasis (P> 0.05). ③ There was no significant difference in the expression of the two proteins in different clinical stages and different degrees of differentiation (P> 0.05). (4) There was no significant difference in tumor size, different age groups and gender (P> 0.05). ⑤MUC-1 andβ-Catenin had synergistic effect in the expression of cardia carcinoma (correlation coefficient 0.9072, P = 0.0001 <0.05).