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目的：探究干扰素γ（ IFN－γ）联合肝素对特发性肺间质纤维化（ IPF）患者肺功能指标及凝血功能的影响。方法选择2014年1月至2015年5月彭州市中医医院收治的80例 IPF 患者为研究对象，采用随机数字表法分为对照组和研究组，各40例。对照组接受常规激素治疗，布地奈德雾化吸入治疗，每日1次；研究组接受IFN－γ联合肝素治疗，使用德国百瑞高效雾化吸入机进行雾化吸入肝素治疗，每次30 mg，每日1次，再接受IFN－γ皮下注射，每次200万U，每日1次。两组治疗均为期1个月。检测比较两组患者治疗前后的临床症状、肺功能指标及凝血指标变化。结果治疗后，研究组患者呼吸困难、咳嗽、胸闷症状好转率分别为60．0％（24／40）、67．5％（27／40）、70．0％（28／40），显著高于对照组的32．5％（13／40）、30．0％（12／40）、37．5％（15／40），差异有统计学意义（ P ＜0．05）。治疗后，研究组肺总量及一氧化碳弥散量高于较对照组[（63±11）％比（58±9）％，（49±8）％比（44±10）％]，差异有统计学意义（P＜0．05）。治疗后，研究组纤维蛋白原、D－二聚体水平低于对照组[（5．76±1．08） g／L比（5．82±1．04） g／L，（0．31±0．16） mg／L比（0．58±0．19） mg／L]，差异有统计学意义（ P＜0．01）。结论 IFN－γ联合肝素治疗IDF能有效减轻患者呼吸困难等临床症状、改善其肺功能及凝血功能，值得大力推广。“,”Objective To investigate the effect of the combination of interferon-γ( IFN-γ) and heparin therapy on lung function and coagulation function of patients with idiopathic pulmonary fibrosis ( IPF ) . Methods Total of 80 cases with IPF admitted to Pengzhou Traditional Chinese Medicine Hospital from Jan . 2014 to May 2015 were selected and randomized into a control group and a study group according to the ran-dom number table method,the control group received conventional treatment,i.e.budesonide inhalation ther-apy,once a day,for one month;the study group received IFN-γcombined with heparin,by German PARI SI-NUS machine,30 mg once,once daily,subcutaneous IFN-γ,2 million U,once daily,for one month.The clini-cal symptoms,lung function indicators and coagulation parameters of the two groups were detectedand ana-lyzed before and after treatment.Results After treatment,the dyspnea,coughing,chest tightness symptom improvement rates of the study group were 60.0%(24/40),67.5% (27/40),70.0% (28/40),signifi-cantly higher than the control group′s [32.5% (13/40),30.0% (12/40),37.5% (15/40)],the differ-ences were statistically significant(P<0.05);lung capacity and carbon monoxide diffusing capacity of the study group were higher than the control group[(63 ±11)%vs (58 ±9)%,(49 ±8)% vs (44 ±10)%], the differences were statistically significant(P <0.05);after treatment,the levels of fibrinogen,D-dimer of the study group were lower than the control group[(5.76 ±1.08) g/L vs (5.82 ±1.04) g/L,(0.31 ± 0.16) mg/L vs (0.58 ±0.19) mg/L],the differences were statistically significant(P<0.01).Conclusion The combination of IFN-γand heparin for treatment of IPF can significantly release the discomfort symp-toms and improve the lung function and coagulation of the patients,thus is worthy of promoting.