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目的 建立糖尿病性胃轻瘫大鼠模型 ,对胃Cajal间质细胞的分布及超微结构变化、胃肠道自主神经病变及胃 5 HT受体的表达变化进行了研究。方法 健康成年雄性SD大鼠随机分为两组 :糖尿病组和正常对照组 ,糖尿病组给予四氧嘧啶4 5mg kg经静脉一次注射 ,正常对照组给予等量生理盐
Objective To establish a rat model of diabetic gastroparesis and to study the distribution and ultrastructure changes of gastric Cajal interstitial cells, the changes of gastrointestinal autonomic neuropathy and the expression of gastric 5 HT receptor. Methods Healthy male Sprague-Dawley rats were randomly divided into two groups: diabetic group and normal control group. Alloxan 45 mg was given to the diabetic group once by intravenous injection. The normal control group was given the same amount of physiological salt