【摘 要】
：
硫酸吗啡控释片为强效中枢性镇痛药物,主要用于中晚期癌症患者的第三阶梯止痛治疗,近年来国内有文献报道其不良如下。1呼吸抑制例1:男,65岁。因原发性肝癌疼痛给予吗啡控释片
【机 构】
：
山东省青岛市第八人民医院药剂科,江苏省南京市鼓楼区宁海路卫生服务中心,
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硫酸吗啡控释片为强效中枢性镇痛药物,主要用于中晚期癌症患者的第三阶梯止痛治疗,近年来国内有文献报道其不良如下。1呼吸抑制例1:男,65岁。因原发性肝癌疼痛给予吗啡控释片30 mg口服,服药1 h后出现恶心,2 h出现胸闷,呼吸困难,呼吸深慢4～5次/min。口唇轻度紫绀,瞳孔缩小2 mm,即予对症治疗,2 h后呼吸逐渐恢复为10～16次/min,4 h后紫绀好转,瞳孔恢复正常,生命体征稳定。例2:女,58岁。因
Morphine sulfate controlled-release tablets for potent central analgesic drugs, mainly for the third stage of advanced cancer patients with pain treatment, in recent years, the domestic literature reported its poor as follows. 1 respiratory depression Example 1: male, 65 years old. Due to the pain of primary hepatocellular carcinoma given morphine controlled-release tablets 30 mg orally, 1 h after taking nausea, 2 h chest tightness, difficulty breathing, breathing slowly 4 to 5 times / min. Mild lips cyanosis, miosis 2 mm, that is to symptomatic treatment, 2 h after respiration gradually restored to 10 to 16 beats / min, 4 h after cyanotic improvement, pupil returned to normal, stable vital signs. Example 2: Female, 58 years old. because
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