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卡托普利(captopril,CPT,巯甲丙脯酸)是一种血管紧张素转化酶抑制剂。随着临床广泛应用,不良反应报道逐渐增多。但该药引起痛风,作者未见报道,现报道1例。患者;男,49a,高血压病3a,一直未有效控制。即于1990年10月4日入院后首次口服CPT(广州白云山制药总厂,批号900602)25mg,bid,3d后血压由原来的22.7/14.7kPa(1kPa=7.5mmHg)降至18.7/11.3kPa。继续用至d16(第16天),突然感到右足(足母)趾关节疼痛,次日红、肿、活动受限。查体:心界向左下扩大;心率80次/min,律齐;在足(足母)指关节红、肿、压痛、活动受限。实验室检查:血白细胞12×10~9/L,中性粒细胞0.80,血沉25mm/1h,
Captopril (CPT, captopril) is an angiotensin-converting enzyme inhibitor. With the wide range of clinical applications, adverse reactions reported gradually increased. However, the drug caused gout, the authors have not reported, is reported in 1 case. Patients; male, 49a, hypertensive 3a, have not been effectively controlled. That is, the first oral CPT (Guangzhou Baiyunshan Pharmaceutical Factory, batch number 900602) 25mg, bid, 3d after the October 4, 1990 blood pressure from the original 22.7 / 14.7kPa (1kPa = 7.5mmHg) dropped to 18.7 / 11.3kPa . Continue to use d16 (Day 16) and suddenly felt pain in the right foot (foot mother) toe joint, with redness and swelling on the following day and limited mobility. Physical examination: the heart to expand to the left; heart rate 80 times / min, law Qi; in the foot (foot mother) refers to the joints red, swollen, tenderness, limited mobility. Laboratory tests: white blood cells 12 × 10 ~ 9 / L, neutrophils 0.80, erythrocyte sedimentation rate 25mm / 1h,