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[目的]探讨胸腔内分别注入白介素-2、博来霉素、顺铂治疗恶性胸腔积液的疗效与毒副反应。[方法]回顾性分析经胸水细胞学确诊为恶性胸腔积液的患者共216例:白介素-2组(A组)80例,胸腔内注入0.9%生理盐水20ml+白介素-2100万U;博来霉素组(B组)72例,胸腔内注入0.9%生理盐水20ml+博来霉素60mg;顺铂组(C组)64例,胸腔内注入0.9%生理盐水20ml+顺铂60mg;间隔1周重复上述治疗,其中白介素-2组每4～5d重复治疗,最多重复4次。观察3组疗效、毒副反应。[结果]A、B、C组总有效率分别为75.0%、70.8%和56.3%,3组比较差异无统计学意义(P>0.05)。治疗后A组寒战、骨髓抑制、消化道反应、胸痛发生率均明显低于B、C组,差异有显著性(P<0.01)。[结论]胸腔内注射白介素-2治疗恶性胸腔积液疗效较好,毒副反应较博来霉素组、顺铂组明显轻,局部刺激较轻,耐受性好,是治疗恶性胸腔积液较好的方法。
[Objective] To investigate the curative effect and toxicity of interleukin-2, bleomycin and cisplatin in the treatment of malignant pleural effusion. [Methods] A total of 216 patients with malignant pleural effusion diagnosed by pleural fluid cytology were retrospectively analyzed. 80 patients in the interleukin-2 group (group A) received intrapleural injection of 0.9% normal saline (20ml + interleukin-21 million U) (B group), 72 cases were injected intrathoracically with 0.9% saline 20ml bleomycin 60mg; cisplatin group (C group) 64 cases, intrapleural injection of 0.9% saline 20ml cisplatin 60mg; Treatment, interleukin -2 group repeated every 4 ~ 5d treatment, up to 4 times repeated. Observation of 3 groups efficacy, toxicity. [Results] The total effective rates of A, B and C groups were 75.0%, 70.8% and 56.3% respectively. There was no significant difference between the three groups (P> 0.05). After treatment, the incidence of chills, myelosuppression, gastrointestinal reactions and chest pain in group A were significantly lower than those in groups B and C (P <0.01). [Conclusion] Intrathecal injection of interleukin-2 in the treatment of malignant pleural effusion has a good curative effect. Compared with bleomycin group, the toxicity of cisplatin is obviously lower than that of bleomycin group. The local irritation is mild and well tolerated. It is the treatment of malignant pleural effusion Better way.