γ,δ-不饱和-β-酮酸酯是合成许多天然产物的重要中间体。合成这类化合物简单有效的方法是用β-酮酸酯的双负离子与醛酮缩合。我们最近的研究工作中需要化合物1作为关键中间体,通过对1的反合成分析可知,需要α-异丙基取代的β-酮酸酯(2)的双负离子3与苯甲醛进行反应来制备,但α-烷基取代的β-酮酸酯的双负离子 γ, δ-Unsaturated-β-keto esters are important intermediates for the synthesis of many natural products. A simple and effective way to synthesize these compounds is to condense aldehydes and ketones with dianions of β-ketoesters. Our recent research work requires Compound 1 as the key intermediate, and by the reverse synthesis analysis of 1, it is known that dianion 3, which requires α-isopropyl substituted β-ketoacid ester (2), is reacted with benzaldehyde , But double anions of alpha-alkyl substituted beta-keto esters