Ip 和 Thompson 在美国国家癌症研究所杂志上发表文章认为:联合使用三氟甲基鸟氨酸(difluoromethylornithine,DFMO)和亚硒酸盐具有协同预防肿瘤的作用,在动物模型,此方案可降低二二甲苯并蒽(DMBA)诱发的乳腺肿瘤的发生率和肿瘤数量。虽然这两种药物的确切化学预防机理尚未明了,但现有的资料可以说明两药联合使用比单独应用具有更好的效果。鸟氨酸脱羧酶(Ornithine decarboxyl-ase,ODC)使鸟氨酸脱羧形成丁二胺,它是哺乳动物多胺、丁二胺、亚精胺及精胺生物合成通道中首要的限速酶,而精胺又是维持细胞周期 S 期正常转运所必须的。精胺和亚精胺是 Ip and Thompson published an article in the Journal of the National Cancer Institute that: The combined use of trifluoromethylornithine (DFMO) and selenite has a synergistic effect in preventing tumors. In animal models, this protocol can be reduced by two. DMBA-induced breast tumor incidence and tumor number. Although the exact chemopreventive mechanism of the two drugs is not yet clear, the available data can show that the combined use of the two drugs has better results than the single use. Ornithine decarboxyl-ase (ODC) decarboxylates ornithine to butandiamine, which is the primary rate-limiting enzyme in mammalian polyamines, butylenediamine, spermidine, and spermine biosynthetic pathways. The spermine is necessary to maintain the normal transport of cell cycle S phase. Spermine and spermidine are