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自从英国学者胡克经过三年的精心磨制,于1665年制造了世界上第一台显微镜,荷兰科学家列文·虎克于1674年首次观察到漂浮在血液中的各种细胞,科学家们就迫不及待地想知道这些血细胞的来源。1909年Maximor提出了造血一元论的猜想,他猜测这些血液中的有形成分(红细胞、白细胞、血小板)均来自同一祖先。但直到20世纪70年代Till和Mccullocl设计了一个有趣的脾结节实验才初步揭开人类造血的神秘面纱,第一次捕捉到了造血干细胞的痕迹。当研究人员给予小鼠致死剂量的放射线照射,这些小鼠的血液细胞数目将极度减少,若不能重建造血机能,小鼠必然死亡。然而当研究人员将同种异体的小鼠
Since British scholar Hooke made the world’s first microscope in 1665 after three years of careful grinding, the first scientist Levin Hooke discovered in 1674 the various cells floating in the blood. Scientists Can not wait to know the source of these blood cells. In 1909, Maximor proposed the hypothesis of hematopoietic monism that he speculated that the tangible components (red blood cells, white blood cells, and platelets) in these blood came from the same ancestor. However, it was not until the 1970s that Till and Mccullocl designed an interesting experiment of spleen nodules to unveil the mystery of human hematopoiesis, capturing the traces of hematopoietic stem cells for the first time. When researchers give a lethal dose of radiation to mice, the number of blood cells in these mice is greatly reduced, and if they can not reconstruct the hematopoietic function, the mice will inevitably die. However when researchers will allogeneic mice