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目的检测原发性恶性骨肿瘤、骨转移性肿瘤患者血清中的I型胶原吡啶交联终肽(ICTP)活性,以评价ICTP在骨肿瘤诊断和鉴别诊断中的意义。方法对2004年本院骨肿瘤科收治的40例恶性骨肿瘤、14例骨转移性肿瘤患者,采用酶免疫测定(EIA)方法测定ICTP活性。结果恶性骨肿瘤组的ICTP活性为(16.33±11.82)μg/L,与健康对照组比较有统计学差异(P<0.01)。而骨转移性肿瘤组ICTP活性为(8.97±6.08)μg/L与对照组相比无统计学意义(P>0.05)。两组骨肿瘤组间也有统计学意义(P<0.05)。结论血清ICTP是反映骨肿瘤骨代谢的一个灵敏而简便的检测指标,并对骨肿瘤的诊断及鉴别诊断具有一定的临床意义。
Objective To detect the ICTP activity of type I collagen in sera of primary malignant and metastatic bone tumors to evaluate the significance of ICTP in the diagnosis and differential diagnosis of bone tumors. Methods Forty patients with malignant bone tumors and 14 patients with metastatic bone tumors admitted to our hospital in 2004 were enrolled in this study. ICTP activity was measured by enzyme immunoassay (EIA). Results ICTP activity in malignant bone tumor group was (16.33 ± 11.82) μg / L, which was significantly lower than that in healthy control group (P <0.01). However, the ICTP activity in bone metastasis group was (8.97 ± 6.08) μg / L, which was not significantly different from that in control group (P> 0.05). There was also a statistically significant difference between the two groups of bone tumors (P <0.05). Conclusion Serum ICTP is a sensitive and simple detection index to reflect the bone metabolism of bone tumor, and has certain clinical significance for the diagnosis and differential diagnosis of bone tumors.