The micro/-nanoscaled functional biointerfaces aroused much interest of their key unit element to present unique functions. So far it is still difficult to describe the whole picture of this process. More and more evidences are beginning to support the theory of ‘‘mirco/-nanotopography-coupled-mechanical(TCM) action’’ into functional biointerfaces.Herein, we aim to highlight TCM action on varied micro/-nanoscaled functional biointerfaces, namely to achieve better understanding of micro/-nanoscaled structures by introducing interfacial mechanical behaviors. In this article, recent progressions on ‘‘TCM on air/liquid/solid-phase biointerfaces in nature’’, ‘‘in vivo TCM behaviors at micro/-nanoscales’ ’,‘‘TCM in micro/-nanoscaled artificial surface with living Cells’ ’ and ‘‘topography, interfacial curvature, mechanics’ ’are reviewed. Certain new concepts of ‘‘TCM action based on spatial curvature’’, ‘‘medically functional biointerfaces’ ’ and‘‘biomechanopharmacology’’ are also proposed. The micro / -nanoscaled functional biointerfaces aroused much interest of their key unit element to present unique functions. So far it is still difficult to describe the whole picture of this process. More and more evidences are beginning to support the theory of ’mirco / -nanotopography-coupled-mechanical (TCM) action ’’ into functional biointerfaces.Herein, we aim to highlight TCM action on varied micro / -nanoscaled functional biointerfaces, namely to achieve better understanding of micro / -nanoscaled structures by introducing interfacial mechanical behaviors. In this article, recent progress on ’TCM in air / liquid / solid-phase biointerfaces in nature’, ’’ in vivo TCM behaviors at micro / -nanoscales’ ’,’ TCM in micro / -nanoscaled artificial surface with living Certain new concepts of ’TCM action based on spatial curvature’ ’,’ ’medically functional biointerfaces’ ’and’ biomechanoph armacology ’are also proposed.