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目的:观察吉祥草总皂苷(TSRC)对实验性Freund′s完全佐剂大鼠镇痛作用的影响,探讨其对抗类风湿性关节炎(RA)的镇痛作用及作用机制。方法:建立佐剂性关节炎(AA)动物模型,采用吉祥草总皂苷(高、中、低剂量组),并设立空白对照组、模型组、中药阳性对照组和西药阳性对照组治疗,观察TSRC对AA大鼠足肿胀度、关节炎指数的影响,并检测其痛阈、疼痛级别等的变化。结果:TSRC能有效抑制关节肿胀率及关节指数,提高AA大鼠痛阈水平。结论:TSRC具有显著的镇痛作用,其作用与所含的总皂苷有关。
Objective: To observe the effect of TSRC on the analgesic effect of Freund’s complete adjuvant in rats and its analgesic effect on rheumatoid arthritis (RA) and its mechanism. Methods: Animal model of adjuvant arthritis (AA) was established. The total saponin (high, middle and low dose) of Jiadongcao was used, and the blank control group, model group, traditional Chinese medicine positive control group and western medicine positive control group were established. TSRC on rat paw swelling, arthritis index, and test its pain threshold, pain level changes. Results: TSRC can effectively inhibit the joint swelling rate and joint index and improve the pain threshold of AA rats. Conclusion: TSRC has a significant analgesic effect and its effect is related to the total saponins contained.